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Clinical course of chronic liver disease

Past research

CANONIC: Chronic liver failure acute-on-chronic liver failure

The CANONIC study, a prospective observational study in 1349 patients with decompensated cirrhosis admitted to 29 European hospitals, aimed to characterize a syndrome that later would be referred to as acute-on-chronic liver failure (ACLF). The CANONIC study has allowed for a comprehensive assessment of the epidemiology, natural history, diagnostic criteria, clinical course, prognosis, prevention and treatment of ACLF.

Investigators

Richard Moreau

MD, PhD
Principal Investigator

Sponsor

EF CLIF, Spain

Research network

  • Hospital Británico de Buenos Aires
  • Hospital de Infecciosas F.J. Muñiz
  • Hospital Italiano de Buenos Aires
  • Hospital Nacional Prof. Alejandro Posadas
  • Hospital Provincial del Centenario
  • Hospital Universitario Austral
  • Botucatu Medical School
  • Escola Paulista de Medicina
  • Faculdade de Ciências Médicas da Universidade Estadual de Campinas
  • Faculdade Regional de Medicina de São José do Rio Preto
  • Hospital das Clínicas da Universidade de São Paulo
  • Hospital das Clinicas da Universidade Federal de Minas Gerais
  • Hospital das Clínicas de Ribeirão Preto
  • Hospital de Base do Distrito Federal
  • Hospital de Clínicas de Porto Alegre
  • Hospital Federal de Bonsucesso
  • Hospital São Rafael
  • Hospital Universitário Cassiano Antonio Moraes
  • Hospital Universitário Clementino Fraga Filho
  • Hospital Universitário Pedro Ernesto
  • Hospital Universitário Professor Edgard Santos
  • Hospital Universitário Walter Cantídio
  • Instituto do Fígado e Transplantes de Pernambuco
  • Irmandade Santa Casa de Misericórdia de Porto Alegre
  • Universidade Federal de Goiás
  • Clínica Las Condes
  • Clínica Universidad de los Andes
  • Hospital Clínico San Borja Arriarán
  • Hospital Clínico Universidad de Chile
  • Pontificia Universidad Católica de Chile
  • Universidad Austral de Chile–Hospital de Base Valdivia
  • Hospital Pablo Tobón Uribe
  • LaCardio
  • Centro Médico Issemym
  • Fundación Clínica Médica Sur
  • Hospital de Especialidades Centro Médico Nacional La Raza
  • Hospital General de México Dr. Eduardo Liceaga
  • Hospital General Juárez
  • Hospital San José Tec de Monterrey
  • Instituto de Salud Digestiva y Hepática
  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
  • Star Médica
  • Universidad Veracruzana
  • Hospital de la Universidad Nacional de Asunción
  • Hospital EsSalud-Arequipa
  • Hospital Nacional Arzobispo Loayza
  • Hospital Nacional Daniel Alcides Carrión
  • Hospital Nacional Edgardo Rebagliati Martins
  • Hospital Nacional Guillermo Almenara

Related News

Differences in percentage of Native American ancestry are associated with the odds to develop severe acute-on-chronic liver failure and risk of short-term mortality in the Latin American population

30 May 2023

Differences in percentage of Native American ancestry are associated with the odds to develop severe acute-on-chronic liver failure and risk of short-term mortality in the Latin American population
Hospital das Clínicas da Universidade de São Paulo in Brazil recruits patient no. 500 in the CHANCE study

28 November 2022

Hospital das Clínicas da Universidade de São Paulo in Brazil recruits patient no. 500 in the CHANCE study
Looking ahead after ACLARA

30 September 2022

Looking ahead after ACLARA
View all news

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European Foundation for the Study of
Chronic Liver Failure
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08021 Barcelona, Spain

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