In patients with cirrhosis neutrophil dysfunction is associated with higher risk of infection. This study aims to assess whether albumin levels could affect neutrophil function and thus contribute to restore the natural defenses against microbes to prevent organ failures and increase survival in patients with acute decompensation and acute-on-chronic liver failure (ACLF). Neutrophil swarming, an essential process of the innate immune response, was tested in vitro. Results have shown that the antimicrobial activity of neutrophils from patients with cirrhosis is impaired in a neutrophil swarming assay. Further investigations are needed to assess whether administration of albumin has a positive effect in restoring neutrophil function in patients with chronic liver disease.