CANONIC: Chronic liver failure acute-on-chronic liver failure

Clinical course of chronic liver disease

CANONIC: Chronic liver failure acute-on-chronic liver failure

The CANONIC study, a prospective observational study in 1349 patients with decompensated cirrhosis admitted to 29 European hospitals, aimed to characterize a syndrome that later would be referred to as acute-on-chronic liver failure (ACLF). The CANONIC study has allowed for a comprehensive assessment of the epidemiology, natural history, diagnostic criteria, clinical course, prognosis, prevention and treatment of ACLF.

Investigators

Richard Moreau

MD, PhD
Principal Investigator

Sponsor

Research network

Austria

Medical University of Graz
Medical University of Innsbruck
Medical University of Vienna

Belgium

CUB Hôpital Erasme
Ghent University Hospital
UZ Leuven

Czech Republic

Institute for Clinical and Experimental Medicine

Denmark

Aarhus University Hospital
Copenhagen University Hospital Hvidov
Rigshospitalet–University Hospital Copenhagen

France

CHU Rennes–Hôpital de Pontchaillou
Hôpital Beaujon
Hôpital Paul-Brousse
Hôpital Pitié-Salpêtrière

Germany

Bonn University Hospital
Goethe University Frankfurt
Hannover Medical School
University Hospital of Munich
University Medical Center Hamburg-Eppendorf

Ireland

St. Vincent’s University Hospital

Italy

Città della Salute e della Scienza di Torino-Presidio Molinette
University of Bologna
University of Padova

Norway

Oslo University Hospital

Spain

Hospital Clínic de Barcelona
Hospital de la Santa Creu i Sant Pau
Hospital General Universitario de Alicante Doctor Balmis
Hospital General Universitario Gregorio Marañón
Hospital Universitari Vall d’Hebron
Hospital Universitario Ramón y Cajal
Hospital Universitario Reina Sofía

Switzerland

University Hospital of Bern

The Netherlands

Erasmus Medical Center
Leiden University Medical Centre

United Kingdom

King’s College Hospital
Royal Free Hospital

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Clinical course of chronic liver disease