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Researchers

Principal InvestigatorsSenior Research AffiliatesResearch AssociatesEmeritus

Salvatore Piano, MD, PhD

The problem

My main research interests are pathophysiology and treatment of complications of cirrhosis: ascites, acute kidney injury (AKI), hepatorenal syndrome (HRS), bacterial infections, and acute-on-chronic liver failure (ACLF).

The approach

I carried out several clinical studies and randomized controlled clinical trials on complications of cirrhosis, which contributed to change the management of patients with chronic liver disease.

Main discoveries and innovations

  • Definition of new diagnostic criteria for AKI and HRS
  • Development of an algorithm for the management of AKI which is currently recommended by EASL clinical practice guidelines
  • Demonstration of the safest strategy to use terlipressin in patients with HRS, how to predict response to terlipressin and albumin in patients with HRS and what is the impact of response to treatment on clinical outcomes of liver transplant candidates/recipients
  • Development of a new protocol of antibiotic treatment for nosocomial spontaneous bacterial peritonitis
  • Clarification of the epidemiology of bacterial infections in cirrhosis worldwide and risk factors for multidrug resistant bacteria
  • Redefinition of sepsis in cirrhosis 
  • Contribution to  understanding the pathophysiology, risk factors, clinical course and outcomes of ACLF

Projects

Biomarkers of renal tubular damage in predicting response to terlipressin and albumin in patients with hepatorenal syndrome

Appointments at EF CLIF

Inspiring and Writing Group
Secretary (2022–present)

Affiliations

University of Padova, Italy
Associate Professor (2024–present)

University of Padova, Italy
Assistant Professor (2018–2024)

Awards & Honors

Rising Star Award, United European Gastroenterology (UEG)
2022

Emerging Leader Award, European Association for the Study of the Liver (EASL)
2022, London, UK

Registered office

European Foundation for the Study of
Chronic Liver Failure
Travessera de Gràcia 11, 7th floor
08021 Barcelona, Spain

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E efclif@efclif.com

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