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When evaluating the risks for invasive fungal infections in a patient, physicians today rely mostly on the absolute neutrophil count. However, absolute neutrophil count as a biomarker is imprecise and often misleading in patients with liver diseases (e.g., cirrhosis).
We designed functional assays for neutrophils that replicate essential aspects of the interaction between neutrophils and invasive fungi in vitro. The key feature that is absent in any of the existing assays is the neutrophil–neutrophil communication aka ‘neutrophil swarming’, an essential activity against invasive fungi.
Massachusetts General Hospital, MA,USA
Principal Investigator (2002–present)
Shriners Hospitals for Children, FL, USA
Senior Investigator (2006–present)
European Foundation for the Study of
Chronic Liver Failure
Travessera de Gràcia 11, 7th floor
08021 Barcelona, Spain
© European Foundation for the Study of Chronic Liver Failure 2024
