Liver pathophysiology

Molecular markers to predict chronic liver failure and to explore its mechanistic pathways in decompensated cirrhosis

The issue

Acute-on-chronic liver failure is a syndrome with dismal prognosis and lack of effective treatment options. Liver transplantation is the only curative therapy, however, only available to a minority of patient due to contraindications and shortage of donor organs. Moreover, having validated predictors and biomarkers would help to select patient for individual treatment strategies

The approach

This project aims to understand the role of bacterial translocation and immune cell-derived microparticles in mediating the progression of cirrhosis to decompensation and acute-on-chronic liver failure in patients within PREDICT – Predicting acute-on-chronic liver failure in cirrhosis.

Establishing new biomarkers is the basis to stratify patients with respect to prognosis as well as diagnostic and therapeutic strategies.