Pierre-Emmanuel Rautou, Coordinator of DECISION and Professor at Inserm–Université Paris Diderot, France, welcomed participants in a brief opening session followed by David Gomez-Cabrero, Head of Translational Bioinformatics Unit at Navarrabiomed, Spain, who talked about patient stratification and shared his insights on systems medicine and omics data analysis. In the afternoon, member of the DECISION Impact Board Narsis Kiani (Karolinska Institutet, Sweden) together with Jonel Trebicka (Goethe University Frankfurt, Germany) and Paolo Caraceni (University of Bologna, Italy) presented potential combinatorial treatment options for acute decompensation of cirrhosis. Next, Sabine Klein and Nico Kraus, postdoctoral and predoctoral researchers, respectively, at Goethe University Frankfurt presented promising results in rat models of decompensated cirrhosis. Members of the Steering Committee met at the end of the day to assess the results presented.

Day 2 started with Joan Clària, Research Associate at EF CLIF and Professor at Clínic Foundation for Biomedical Research (FCRB), who presented the first results from 1.5 years of extensive characterization of samples from patients with decompensated cirrhosis using high-throughput omics technologies. Cristina Sánchez, Head of the Data Management Center at EF CLIF, reviewed the infrastructure to support data management and explained how to request access to the DECISION data hub. Ameli Schwalber, Chief Executive Officer and Dissemination Manager at Concentris, Germany, provided an update on activities releated to commuications, dissemination, exploitation and training. Itziar de Lecuona, Deputy Director of the Bioethics and Law Observatory at University of Barcelona, Spain, provided an update on ethics approval and regulations. Next, Isabelle Durand-Zaleski, Professor at University of Paris XII, France, discussed about the impact of the DECISION project outcomes on health and socioeconomics at large. Rautou chaired a final session where major challenges were further discussed.